Express Scripts Customer Care Phone Number: How to Reach the Right Team Quickly

Express Scripts manages pharmacy benefits and home-delivery prescriptions for tens of millions of members across employer plans, Medicare, Medicaid, TRICARE, and other programs. Because contact routes can differ by plan, the fastest way to get help is usually the number printed on your pharmacy ID card or in your Express Scripts account. That said, several widely used lines are consistent across programs and available 24/7 for most member needs.

If you’re looking for a single, general member-support line for the home-delivery pharmacy and common benefit questions, call Express Scripts Pharmacy Member Services at 800-282-2881. You can also access secure chat and request a callback by signing in at express-scripts.com or using the Express Scripts mobile app (iOS and Android). Members who are deaf, hard of hearing, or have a speech disability can dial 711 to use the Telecommunications Relay Service (TRS) with any number listed here.

Primary Lines and When to Use Them

Different programs within Express Scripts are supported by dedicated teams. Using the right number helps you bypass transfers, verify coverage faster, and resolve claim or delivery issues in a single call. Have your Member ID and a recent prescription number ready to speed identity verification.

Below are commonly used, publicly listed contact routes that cover the majority of member scenarios. If your plan provides a different number on your ID card or in your online account, use that plan-specific number first.

• General Member Support (Express Scripts Pharmacy): 800-282-2881 — For home-delivery orders, copays, claim questions, prescription status, address/payment updates, and benefit questions for most commercial plans. Available 24/7.
• TRICARE Pharmacy Program (Department of Defense): 877-363-1303 — For retail and home-delivery claims, network pharmacies, prior authorizations, and formulary questions under TRICARE. 24/7 support; TTY users dial 711. Official site: militaryrx.express-scripts.com.
• Accredo (Specialty Pharmacy, an Express Scripts company): 866-344-4874 — For specialty medications that require special handling, nursing support, or prior authorization coordination. Use this line for onboarding, benefits investigations, financial assistance screening, refill scheduling, and temperature-controlled delivery questions.
• Prescriber Prior Authorization Help Desk (Providers only): 800-753-2851 — For physicians and clinical staff to initiate or check the status of prior authorization requests, provide clinical documentation, or discuss step-therapy edits.
• Corporate Office Switchboard (not for benefit lookups): 314-996-0900 — Switchboard for Express Scripts/Evernorth at One Express Way, St. Louis, MO 63121. Use member support lines above for HIPAA-protected account help.

What to Have Ready Before You Call

Having the right details at hand reduces average call time and helps the representative resolve issues without call-backs. At minimum, keep your Member ID (from your pharmacy card or online account), date of birth, and a recent prescription number (the “Rx#” on your bottle or order) nearby. If you’re calling about a dependent, you may need the dependent’s information, not just the policyholder’s.

For claim or copay disputes, have the pharmacy name and phone, the date the prescription was filled, the National Drug Code (NDC) if available, and the paid receipt or claim number. For home delivery, have your current shipping address, any known travel dates, and a valid payment method. If you’re a caregiver or calling on behalf of someone else, ensure an authorization is on file; HIPAA rules limit what can be discussed without documented permission.

Digital Options That Can Be Faster Than Calling

If your question is routine—like order status, refill timing, or price checks—the Express Scripts mobile app and web portal often provide instant answers. After signing in at express-scripts.com, you can track shipments in real time, update payment and delivery preferences (including weekend delivery or signature requirements), and view plan-specific copays and alternatives. Many members also use the Drug Pricing tool to compare retail vs. home-delivery costs before ordering.

Secure chat within the app or website connects you to a live agent with your account context already on screen. That can be faster than navigating phone menus, especially during peak hours (weekday mornings and early evenings). You can also set refill reminders, enable auto-refill for eligible medications, and receive proactive alerts if a prescription needs your prescriber’s renewal approval.

Common Issues and How to Get Them Resolved Quickly

For “prior authorization required” messages at the pharmacy, call the member line listed above to confirm whether your plan requires prior authorization, step therapy, or quantity limits for that specific drug. If PA is needed, contact your prescriber and share the provider help desk number (800-753-2851) so the office can submit the clinical rationale the same day. Having tried-and-failed medication history and relevant lab values ready with your prescriber speeds approvals.

For shipping delays, check your online order status first—weather holds, address verification, or prescriber renewal may be the cause. If a replacement is needed due to carrier loss or temperature excursion, call member support promptly; many temperature-sensitive drugs must be replaced within strict timelines to maintain integrity. If you’re traveling, ask about vacation overrides, early refills, or temporary retail fills to avoid interruptions.

Costs, Hours, and Practical Notes

Member support lines listed here are toll-free in the U.S. Standard mobile minutes may apply. Express Scripts’ core member support is staffed 24/7, including weekends and most holidays, though certain specialty or clinical teams may observe specific hours. If you are outside the U.S., use secure chat or the number on your ID card for guidance on international dialing and delivery options.

Express Scripts and Accredo can often identify lower-cost therapeutic alternatives or 90-day supply options that reduce annual out-of-pocket costs. If you’re on a high-deductible plan, ask for the negotiated rate and whether home delivery could reduce dispensing fees. Always confirm prices shown online at checkout; taxes, dispensing fees, and plan year changes (typically January 1) can alter final copays.

Official Websites and Addresses

Main site for members: express-scripts.com. TRICARE members: militaryrx.express-scripts.com. Corporate address: One Express Way, St. Louis, MO 63121 (Evernorth/Express Scripts campus). For the most accurate mailing addresses for prescription submissions, payments, or written appeals, use the instructions provided in your online account or on your plan’s Explanation of Benefits (EOB), as addresses vary by program and state.

If the number on your ID card differs from the numbers above, treat the ID card number as authoritative—it routes your call to a team that can see your exact plan rules and claim history. If you’ve lost your card, sign in online or via the app to retrieve your plan’s preferred contact details and request a digital or mailed replacement card.